IgG Donor-Specific Anti-Human HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury
نویسندگان
چکیده
منابع مشابه
Donor-Specific HLA Antibody IgG Subclasses Are Associated with Phenotypes of Antibody-Mediated Rejection in Sensitized Renal Allograft Recipients.
Donor-specific anti–histocompatibility leukocyte antigen antibodies (DSAs) have a strong and frequently considered universally deleterious effect on allografts. Preformed or de novo DSAs activate complement, induce endothelial cell proliferation, and mediate antibody-dependent cellular cytotoxicity (ADCC), resulting in progressive declines in allograft function and loss.1–3More than 5000 renal ...
متن کاملAntibody-Mediated Kidney Allograft Rejection
Successful kidney transplantation improves the quality of life and increases survival when compared with long-term dialysis. Renal transplantation is now a well established and the preferred treatment for most patients with end-stage renal disease (ESRD). In recent years, the short-term effects of kidney transplantation have been greatly achieved due to the improvement in immunosuppression medi...
متن کاملAnti-HLA Antibodies and Kidney Allograft Outcomes in Recipients with Donor Bone Marrow Cell Infusion
Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (DBMI). Methods: Between June 2006 and May 2007, forty living unrelated donor kidney tra...
متن کاملDeceased donor kidney transplantation across donor-specific antibody barriers: predictors of antibody-mediated rejection.
BACKGROUND Apheresis-based desensitization allows for successful transplantation across major immunological barriers. For donor-specific antibody (DSA)- and/or crossmatch-positive transplantation, however, it has been shown that even intense immunomodulation may not completely prevent antibody-mediated rejection (ABMR). METHODS In this study, we evaluated transplant outcomes in 101 DSA+ decea...
متن کاملClinical significance of the presence of anti-human leukocyte antigen-donor specific antibody in kidney transplant recipients with allograft dysfunction
BACKGROUND/AIMS This study investigated the clinical significance of detecting anti-human leukocyte antigen-donor specific antibody (HLA-DSA) in kidney transplant recipients (KTRs) requiring indication biopsy owing to allograft dysfunction. METHODS We analyzed the presence of HLA-DSA in 210 KTRs who took indication biopsy. We divided these cases into two groups, HLA-DSA (+) (n = 52) and HLA-D...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2015
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2014111120